NCI Well Connect Mid-Week Brief
May 20, 2015
Dear Steve, 

DID YOU KNOW that the FDA just added major warnings to the labels of two classes of our most commonly used medications?

Labels of the entire class of bone drugs called bisphosphonates and agiogenesis inhibitors (Actonel, Boniva, Fosomax, etc.) now states, "risk of osteonecrosis of the jaw with the concomitant use of bisphosphonates and angiogenesis inhibitors."

Labels of the class of stimulants for attention-deficit disorders (Adderall, Ritalin, Strattera, etc.) now includes "rhabdomyolysis". You may recall seeing this on the labels of statin medication. According to National Institutes of Health, "rhabdomyolysis is the breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood. These substances are harmful to the kidney and often cause kidney damage."

We have known about the connection between necrosis of the jaw and bone drugs for a while. We were not aware of the link between stimulants and rhabdomyolysis. Yikes!

RECAP: If you missed Monday's piece on Cyberchondria, go to this link.
Probiotic Straw That Stirs the Digestive Drink?
Steve: A new study from journal mBio suggests that a single strain of probiotic behaves less like a soloist and more like the conductor of an orchestra that gets the intestines' diverse microbial artists to play in harmony. The result: a happy, energized and harmonious community of musicians.

Researchers have recognized for some time that boosting Lactobacillus rhamnosus, also called Lactobacillus GG (LGG), in the gut can help with intestinal problems, respiratory infections and some skin disorders. LGG adheres to the mucous membrane of the intestinal wall. But how it works has been a mystery.

Participants took Lactobacillus rhamnosus twice a day for 28 days. Researchers discovered an increase in the number and activity of genes in the lining of the gut that nurtured existing populations of other bacteria, including Bacteroides, Eubacterium, Faecalibacterium, Bifidobacterium and Streptococcus, all of which have benefits, including maintaining and improving immune system function. The genes that saw an increase allowed bacterial cells to move better within their environments and to respond to other chemicals inside the gut.

So rather than acting directly on the gut or boosting the diversity of the microflora in subjects' guts, LGG may promote interactions between bacterial colonies in the gut and the gut itself.

The takeaway? It would be a good idea to supplement with a 30 day supply of LGG every three months in addition to your daily probiotic.
Block a Sugar Craving
In a recent study in Appetite, researchers found a novel method to curb preference for, and that led to, more negative attitudes toward sugar-sweetened beverages.

The thinking was that if people could concretely visualize the quantity of sugar in one sugar-sweetened beverage (pictured right), they would have more negative views toward the idea of consuming 28 sugar cubes (concrete information), compared to consuming 70 grams of sugar (abstract information).

Study subjects struggled to convert sugar grams into concrete, physical sugar representation. Yet, when they were able to visualize sugar content, they found sugar-sweetened beverages less attractive and were less likely to choose them.

Bonnie: Seems so simple because visuals have lasting impressions. I still have long-time clients check in to see the 33 year-old Hostess Cupcake in my office. It is one of the most powerful visuals I've had at my disposal. 


Thirty years of serving your wellness needs. We appreciate your continued patronage and support.

Have a happy, healthy day,
Bonnie, Steve, and all of us at Nutritional Concepts
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