Nutritional Concepts Inc.
In This Issue
Well Connect Feature
Did You Know?
Recipe du Jour
Shrewd Shopper
Brand Buzz
Bonnie's Bite
Lab Tests 101
Green Lifestyle
Wild Card
eNews Updates
Well Connect
Do-It-Yourself Beauty
30-Day Diet Plan

New Bloodwork?
Schedule Your Apt
 With Bonnie ASAP.

Food Intolerance: the Silent Assassin
Food Intolerance: 
the Silent Assassin
Wellness Links
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NCI Well Connect
June 3, 2013
Dear Valued Subscriber, 


Did you know that by reading an eNewsletter such as this, you are helping yourself adhere to optimal wellness? It is called IBCT, or, Interactive Behavior Change Technology. 


Just reading about ways to improve your well being or avoid participating in negative wellness behaviors can be significant. A recent study in Journal of the American Board of Family Medicine discovered that one minute was the average amount of time primary care physicians can devote to prevention during a typical office visit. 7.4 hours per day would be required for a physician to devote recommended preventive care services to an average patient panel. This is impossible to accomplish in our current health care environment. 


However, the study found that IBCT, through emails, eNewsletters, interactive websites, and apps, assisted patients with making positive changes in their behaviors, especially with activity, diet, and other lifestyle choices. 


Take your wellness to the next level by subscribing to NCI Well Connect eNewsletter. For the month of June, NCI Well Connect is 40% off the regular price (49.99 from 79.99).


Please enjoy today's complimentary issue of NCI Well Connect.Below is an example of what you will receive on a weekly basis.


Have a happy, healthy week. Bonnie and Steve Minsky


Well Connect Weekly Feature:
Vitamin D Sparkles


Several times per year we disseminate the best research on vitamin D and share the highlights with you. Following are from January to present. There should be something for everybody!


Breast Cancer

In comparison with those in the highest category of vitamin D status for this population, invasive breast cancer cases were much higher for women with a serum 25(OH)D concentration below 10, according to an upcoming study from American Journal of Clinical Nutrition.


Active vitamin D3, calcitriol, was used as an experimental approach to fight inflammatory breast cancer, an especially deadly form of breast cancer. Quantum dots, an engineered light-emitting nanoscale delivery vehicle, rapidly moves high concentrations of calcitriol to targeted tumor sites where cancer cells accumulate, and also through the lymph system where the cancer spreads. With this approach, the calcitriol can fight on multiple fronts and the targeted location can be visualized with an imaging system tracking the quantum dots. The research was presented at the Annual Meeting of the Biophysical Society.


Dental Caries
A Nutrition Reviews study identified vitamin D as a promising caries-preventive agent, leading to a conclusion that vitamin D may reduce the incidence of caries.



A study from Clinical Nutrition found that people with vitamin D levels of at least 75 had a 43% lower risk of depression, compared to people with vitamin D levels lower than 25. Results also indicated that higher vitamin D levels were associated with a 67% lower risk of panic.   


A government study among US active-duty military personnel with serum in the US Department of Defense Serum Repository found that in non-Hispanic whites, those with average 25(OH)D levels of more than 100 had a 44% lower risk of developing Type 1 Diabetes than those with average 25(OH)D levels below 75.


Food Allergy
In the March issue of Journal of Allergy and Clinical Immunology, serum taken from 5,000 babies found that those with low vitamin D levels were three times more likely to have food allergy.   



A study in published in PLOS ONE reveals for the first time that improvement in the vitamin D status of healthy adults significantly impacts genes involved with a number of biologic pathways associated with cancer, cardiovascular disease, infectious diseases and autoimmune diseases.


According to findings in the British Journal of Nutrition, vitamin D3 reduced PTEN methylation and induced its expression without notable effects in combined treatments. The present results suggest that vitamin D can find application in epigenetic anticancer therapy aimed at inhibition of promoter methylation of tumor suppressor genes and induction of their expression at early stages of carcinogenesis.


Inflammatory Bowel Disease

The link between vitamin D and inflammatory bowel disease was strengthened by two studies reported at Digestive Disease Week 2013. In one study, vitamin D deficiency was associated with increased hospitalization and surgery related to inflammatory bowel disease. In a separate study, patients in remission with Crohn's disease who took vitamin D supplements and whose blood levels of 25-dihydroxyvitamin D were at or above 30, had a 24-point increase in quality of life score and exceeded the 20-point increase that is considered clinically meaningful to patients and physicians.


Metabolic Syndrome

The prevalence of 25(OH)D deficiency increased with obesity. The prevalence of hyperparathyroidism increased from 12% in non-obese to 47.5% in morbidly obese individuals. Data from this Cardiovascular Diabetology study supports a possible contribution of plasma 25(OH)D to the pathogenesis of hypertriglyceridemia and diabetes through inflammation.

Correcting vitamin D insufficiency in obese adolescents improves insulin sensitivity, according to new study from American Journal of Clinical Nutrition. Serum leptin to adiponectin ratio was also significantly lower in the vitamin D group than in the placebo group at six months.


Multiple Sclerosis

Low levels of (25(OH)D) are associated with a higher incidence of multiple sclerosis due to the immune suppressive properties of vitamin D. In theBMC Neurology study, 25(OH)D is an immunomodulatory molecule that might have a regulatory role in T-cell proliferation to myelin peptides in multiple sclerosis patients.  


Parkinson's Disease
Compared with the placebo, vitamin D3 (1200IU per day) significantly prevented the deterioration of the HY stage in patients with Parkinson's Disease. Vitamin D3 supplementation may stabilize PD for a short period in patients with FokI TT or CT genotypes without triggering hypercalcemia, as reported in the March issue of American Journal of Clinical Nutrition.   



According to a findings in BMJ, low vitamin D3 levels during pregnancy were associated with an increased risk for gestational diabetes, pre-eclampsia, and risk of small-for-gestational age infants. 


Preterm Infants

Vitamin D supplementation is recommended for preterm infants both while they are still in the hospital and after discharge, according to dietary guidelines in Pediatrics. For vitamin D supplementation, intake of 200 to 400 IU per day for preterm infants is recommended. This intake should be increased to 400 IU per day when weight exceeds about 3.5 pounds and the infant is tolerating full enteral nutrition.


Pulmonary Function

Hypovitaminosis D may be a risk factor for lung dysfunction, especially for overweight and obese men living in Northern countries, according to aAmerican Journal of Clinical Nutrition study.

Vitamin-D deficiency is common in bronchiectasis and correlates with markers of disease severity, according to a recent study in Thorax.


Rheumatoid Disorders
Many autoimmune rheumatological disorders appear to be associated with vitamin D deficiency and in some cases this extends to an association with disease activity. Genes involved in vitamin D metabolism are also associated. This is a major acknowledgement from Current Opinion of Rheumatology.


According to Therapeutic Advances in Endocrinology and Metabolism, vitamin D deficiency is highly prevalent in patients with Rheumatoid Arthritis, and that vitamin D deficiency may be linked to disease severity in RA. As vitamin D deficiency has been linked to diffuse musculoskeletal pain, these results have therapeutic implications. Vitamin D supplementation may be needed both for the prevention of osteoporosis as well as for pain relief in patients with RA.


Skin Color
African-American women battling vitamin D deficiencies need the same dose as Caucasian women to treat the condition, according to a study inJournal of Clinical Endocrinology & Metabolism. Although women with darker skin tones tend to have lower vitamin D levels, the study found that older African-American and Caucasian women responded in the same way when they received the same dosage of vitamin D supplements.   


A Clinical Endocrinology study compared the efficacy of high-dose intramuscular and oral vitamin D3 in treatment of hypovitaminosis D. Participants were randomly assigned to receive 300,000 IU cholecalciferol, either intramuscularly as a single injection or orally in six divided doses during 3 months period. 


Both treatment regimens significantly increased the serum 25(OH)D level (oral was slightly superior) and were safe in treating hypovitaminosis D.


Steve: We posted this specifically to show that high, short-term dosing at these high levels in deficient individuals is safe. 


Uterine Fibroids

Women with sufficient levels of vitamin D were 32% less likely to develop uterine fibroids, noncancerous tumors that are the leading cause of hysterectomy, according to an article from the May issue of Epidemiology.


Did You Know? Medications
No Way to Avoid Drug Side Effects?      
A new study of both computer-created and natural proteins suggests that the number of unique pockets -- sites where small molecule pharmaceutical compounds can bind to proteins -- is surprisingly small, meaning drug side effects may be impossible to avoid. 
The likelihood that a molecule intended for one protein target will also bind with an unintended target is significant, said researchers in Journal Proceedings of the National Academy of Sciences. The study provides a rationalization for why a lot of drugs have significant side effects. 


To counter the impact of unintended effects, drug developers will need to know more about the available pockets so they can avoid affecting binding locations that are also located on proteins critical to life processes. If the inevitable unintended binding takes place on less critical proteins, the side effects may be less severe.

Bonnie: As we have discussed, genetic testing will help minimize side effects, but to what degree we will not know until we crack the code on how all the genes work together.  
Recipe du Jour
Grain-Free Chocolate Chip Cookies.    

-2 cups blanched almond flour
-2 tablespoons coconut flour
-1/2 teaspoon sea salt
-1/2 teaspoon baking soda
-1 tablespoon vanilla extract (use double strength, optional)
-1/2 cup ghee or coconut oil (or butter), melted
-1/2 cup coconut nectar (maple syrup works well too)
-3/4 cup dark chocolate chips (70% cocoa)

Preheat oven to 350 degrees. Combine dry ingredients in a large bowl. Combine wet ingredients in a small bowl. Mix wet ingredients into dry ingredients. Use a small cookie dough scoop or form into 1/2 inch balls and place on a parchment paper lined cookie sheet. Press dough down onto pan to form round disks. (The dough does not automatically melt and spread out as with regular flour.) Bake 10 minutes. (a little longer if you like a crunchier cookie). Remove to a wire rack to cool. 
Makes 30-36 cookies.

Shrewd Shopper
Supplement Pain Protocols      

Here are the best drug-free protocols for three of the most common types of pain. Unlike pain meds that block pain, these substances work harmoniously with pain triggers.



Hops Extract

Potent B-Complex

Gamma Linoleic Acid (GLA)

Alpha Lipoic Acid



Hops Extract

EPA/DHA Fish Oil


Boswellia or Ginger


Soft Tissue

Hops Extract


Proteolytic Enzymes (Papaya or Bromelain depending on sensitivity)


Steve: Please consult your licensed health professional with expertise in these supplements for dosage that is ideal for you.

Does Knuckle Cracking Lead to Osteoarthritis?
According to a study from Journal of the American Board of Family Medicine, researchers examined persons aged 50 to 89 years who received radiographs of the right hand during the last 5 years. Patients had radiographically proven hand osteoarthritis, and controls did not. Participants indicated frequency, duration, and details of their knuckle cracking behavior and known risk factors for hand osteoarthritis.


The prevalence of knuckle cracking was 20%. The prevalence of osteoarthritis in any joint was similar among those who crack knuckles (18.1%) and those who do not (21.5%). When examined by joint type, knuckle cracking was not a risk for osteoarthritis in that joint. Total past duration (in years) and volume (daily frequency x years) of knuckle cracking of each joint type also was not significantly correlated with osteoarthritis at the respective joint.

Brand Buzz

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It actually alerts you when you need to replace the filter.

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Miller Poultry

Amish farm in Indiana that raises organic, antibiotic-free poultry.

Go to


Bonnie's Bite
Healing Fissures With Food.
With almost any client who has come to me see about recurring anal fissures, removing foods that trigger inflammatory/toxic reactions heal the issue. While I see this consistently in my practice, I have never seen it in a journal.
In a study in the May issue of American Journal of Gastroenterology, a diet that curbs food intolerance help chronic anal fissures to heal. Roughly a fifth of patients whose fissures healed had recurrence on double-blind placebo-controlled challenge with wheat and/or cow's milk proteins, but didn't react to placebo administration. The study suggests that anal fissures might be at least partly related to a high resting anal pressure due to unrecognized food intolerance.

The researchers randomly assigned patients to follow one of two diets for eight weeks. The first was a "true oligo-antigenic diet." It eliminated cow's milk and its derivatives, as well as wheat, egg, tomato, and chocolate. The "sham diet" eliminated rice, potato, lamb, beans, and peas.

All patients also received treatment with sitz baths and bran supplementation during the eight weeks of the study, plus topical nifedipine 0.3 % and lidocaine 1.5% cream three times daily.

By the end, the anal fissures had healed completely in 69% of the "true diet" and 45% of the "sham diet" group. The intervention group also had a significantly higher number of evacuations per week in the second half of the study. 

In a second phase of the study, patients who were cured on the oligo-antigenic diet were challenged with cow's milk protein or wheat, or placebo. While no one reacted to the placebo, many had fissure recurrence during the two-week cow's milk challenge and wheat challenge.
Understanding Lab Tests
Screening for Vitamin E Levels.

According to new research in the Journal of Internal Medicine, researchers evaluated the use of magnetic resonance imaging (MRI) and measures of plasma levels of vitamin E forms - including all eight natural vitamin E congeners (four tocopherols and four tocotrienols) - in differentiating individuals with Alzheimer's disease (AD) and mild cognitive impairment (MCI) from cognitively intact control subjects. 


Consistent with previous research findings, both AD and MCI patients had lower blood plasma levels of different vitamin E isomers, compared to CTL subjects. The results suggest the potential role of nutritional biomarkers detected in plasma-tocopherols and tocotrienols as indirect indicators of AD pathology, and the utility of a multimodality approach.


Alpha and gamma-tocotrienol, as well as gamma-tocopherol were the most important vitamin E forms in differentiating AD and MCI cases from controls. 


Bonnie: This study adds further to the evidence that increased levels of full spectrum vitamin E in the plasma is beneficial for improvement of cognitive functions.


Green Lifestyle
The Effects of Noise Pollution.

Noise is an environmental stressor that stimulates the body's sympathetic nervous system and the hypothalamus-pituitary-adrenal axis, leading to increased blood pressure, heart rate, and levels of the "stress hormone" cortisol. 


Past research has associated exposure to traffic noise with cardiovascular disease, and the mechanisms of action hypothesized to underlie this association suggest that noise may also increase diabetes risk. Investigators now report that long-term exposure to residential road traffic noise was, in fact, associated with increased diabetes in a recent study published in Environmental Health Perspectives.


The investigators used SoundPLAN, a model that incorporates data from a Danish national road and traffic database on number of vehicles, distribution of heavy and light vehicles, road type, and building characteristics. For each address they also estimated railway and airport noise as well as traffic pollution, which has been associated with diabetes in other studies. 


Each 10-decibel increase in average road traffic noise at the current residence was associated with a statistically significant 8% increased risk of incident diabetes.


Steve: Amazing that reducing urban noise could improve population health, and specifically reduce the risk of diabetes. Future studies should seek to determine how traffic noise and air pollution interact to influence the risk of this disease.


Wild Card
High Intensity Acupuncture.

Results of a study in Canadian Medical Association Journal suggest that use of an acupuncture approach that achieves intense stimulation, calledde qi, was associated with better recovery of facial muscle function in patients with Bell's palsy versus acupuncture without such stimulation. 


There is a long-held belief in the traditional theory and clinical practice of acupuncture that the intensity of the stimulus must reach a threshold to elicit de qi, which plays a pivotal role in achieving the best therapeutic effects. 


Among patients with Bell's palsy, acupuncture with strong stimulation that elicited de qi had a greater therapeutic effect, and stronger intensity of de qi was associated with the better therapeutic effects. Acupuncture with de qi was associated with improved facial muscle recovery, disability, and quality of life. 


The authors conclude de qi and its related techniques should be properly appreciated in acupuncture practice and research, and should be considered for inclusion in clinical guidelines for acupuncture.


eNews Updates
eNewsThis week's topics:
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Why NCI Well Connect?

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Utilizing our decades of clinical experience to discern what is fact or fiction, we pore over 400 journals and media weekly to find the ideal nutrition and lifestyle tips that will motivate you to adhere to, or improve upon, your wellness goals.


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Do-It-Yourself Beauty Products!
Burst the Juice Cleanse Bubble with Carolyn Martinelli
Burst the Juice Cleanse Bubble with Carolyn Martinelli

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One of the perks of being a NCI Well Connect subscriber is that you are granted monthly access to our Action Plan Library (27 plans with a total value over $200) and Special Reports. 


The perk comes in handy for those want to follow a 30 day menu created by Bonnie. Our Take Action Plan Diet Plan provides a thirty day menu, regular or gluten-free, complete with recipes, pantry essentials, and shopping list.


If you are not an NCI Well Connect subscriber, you can purchase Take Action Diet Plan separately in Gluten-Free or Regular versions. For NCI Well Connect subscribers, they are free by email request.

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eInspire Quote of the Week.

"If you can't fly then run, if you can't run then walk, if you can't walk then crawl, but whatever you do you have to keep moving forward.

-Martin Luther King 


Have a happy, healthy day.

Bonnie, Steve, and the staff at Nutritional Concepts Inc.

Copyright 2013 Nutritional Concepts Inc.