NCI Well Connect
January 29, 2018
Dear Steve, 

DID YOU KNOW that in a long-term study from last week's JAMA Internal Medicine, breastfeeding for six months or longer cut the risk of developing type 2 diabetes in half for women throughout their childbearing years?

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Have a happy, healthy day! Steve and Bonnie
 
NCI Well Connect Highlights
Steve Minsky
From Editor Steve Minsky
Click the links below to be taken directly to each story. This may not work for all email services.
Read stories like these twice weekly from our eNewsletter, access two titles per month from our Action Plan Library, and get one free wellness coaching session with an NCI Well Connect Membership Here Today!
Organic
Genetic Wellness Takes Center Stage
Bonnie and Steve: As if you needed more reasons to map your genome, a recent study in Annals of Medicine found that one in five subjects screened for their entire genome unknowingly had one or more DNA mutations that increased the risk for genetic diseases, even rare diseases. In addition, every sequenced patient carried at least one recessive mutation linked to a disease, a single copy of a mutant gene that could cause an illness if two copies are present.

Here are a bevy of new genetic studies to whet your whistle.

Detox
GSTP1, one of the SNPs we screen for in our Pure Genomics panel, is a crucial detoxification pathway. A study in the October 2017 issue of Journal of the American College of Nutrition found that those with mutations of this gene showed improvement with increased fiber and vitamin C intake.

Dopamine
DRD2, another SNP in our Pure Genomics panel, shows us how well you produce and detoxify dopamine, a crucial brain neurotransmitter. Studies in January issues ofAppetite and Cell Reports found that young children who exhibited mutations of this gene, either partial or full, have an increased craving for sugar. Sugar can trigger dopamine excitement, and when your dopamine-depressed individuals get that jolt, they crave more of what created the jolt.

Knowing the state of our DRD2 gene is also crucial because dopamine influence our decisions to engage in certain behaviors, like taking drugs, and feelings of reward.

Worrier or a Warrior?
Once we screen your COMT gene, we can tell you if you are a worrier or warrior with certainty.

COMT is an enzyme that is the last stop in the all-important methylation cycle, the most important detoxification pathway. Stress tolerance, cognitive performance, response to stimulants and certain medications, estrogen metabolism, and predicting autoimmune disorders and other chronic disorders are all associated with COMT mutations.

Methylation
Why is understanding our methylation cycle important? One of the hundreds of reasons were elucidated in a recent Genomic Medicine study that found merit to testing DNA methylation patterns in women at risk or had breast and ovarian cancer.

One of the associations between methylation and cancer progression is the body's ability, or lack thereof, to utilize folate for the production of healthy cell production. Unmetabolized folic acid may reduce the uptake of 5-MTHF, the bioactive form of the vitamin. In fact, research in Journal of Cardiovascular Pharmacology found that long-term exposure to synthetic folic acid could lead to lower 5-MTHF, which has a number of potential harmful consequences. These include disruption of methylation of DNA, RNA and proteins, as well as endothelial dysfunction. We screen for MTHFR genes in our Pure Genomics profile. If mutations are an issue, the genetic component can be easily circumvented.

Healthy Diet Bests Bad Genes, Thus Genes Are 'No Excuse' for Obesity
Older health professionals who adhered to a healthy eating pattern were less likely to gain weight over a 20-year follow-up than their peers. In fact, adhering to a healthy diet was most beneficial in individuals who had a high genetic risk for obesity. Researchers in this month's BMJ study screened subjects for the FTO gene, which is part of our Pure Genomics screening.

Alzheimer's Link to Fat, EPA and DHA
A study in PLOS Medicine discovered that how well or poorly you transfer fats and oils genetically into brain and heart-healthy EPA and DHA can make all the difference in memory and cognition later in life. FADS, the most well-researched gene associated with this fat and oil transfer, is part of our Pure Genomics profile.

BDNF
Brain Derived Nerve Growth Factor (BDNF) is one of the key proteins in brain plasticity and offers many insights in brain health and cognitive decline. BDNF enhances neurogenesis, neuronal differentiation and synaptogenesis, modulates appetite, enhances telomerase activity, supports development and maintenance of central nervous system function, enhances long-term potentiation in the hippocampus, and inhibits injury related apoptosis. Lower gene expression of BDNF is found in patients with Alzheimer's, Parkinson's, depression and obsessive-compulsive disorder.

Where can you test for this gene? You guessed it...our Pure Genomics panel.

Vitamin A
In a recent clinical trial in Journal Immunity, scientists found a possible link between retinoic acid, a compound produced in your body from vitamin A, and the inhibition of colon cancer. It is crucial to know how well we genetically transfer beta carotene from food into usable vitamin A. I bet you can guess where you can find this out?

Clinical Look at a Rather Remarkable Family...
We have worked with members of this family of five: mom, dad, and three children, two adult females and an adult male for a number of years now. Along with amassing a good deal of laboratory data, we've recently gathered their genetic data.

This family is homozygous (double mutation) for the COMT mutation.

Creativity: Four musicians, a graphic artist, a potter, three published writers.

Focus: A PhD, an engineer, a physician.

Addiction: Strong family history of addiction, including alcoholism, smoking, pathological gambling, food addiction.

Mental health: Including PTSD, anxiety disorder, depression.

Estrogen excess: Both daughters have uterine fibroids and fibrocystic breast disease. The maternal grandmother had breast cancer. (Remember that COMT is also needed for estrogen metabolism, and in some studies the mutation has been associated with increased risk for breast cancer and fibroids.)

Relevant family history includes a maternal cousin with schizophrenia.

Methylation defects: Elevated homocysteine. The four members who were tested were found to have significantly elevated levels

Knowing the collective familial genetic pattern has helped us greatly in pinpointing multiple techniques to employ that can safely minimize negative expression of COMT not just for them, but for future generations.
Genetics
Pure Genomics Wellness Testing

Bonnie and Steve:It only takes a few simple steps to get individualized genetic nutritional support. Test your genome. We translate the results in a way you can understand. We target your individualized needs with nutritional support that can be easily implemented.

Pure Genomics helps the patient with:
  1. Reaffirmation for why existing patients should continue to adhere to their optimal diet and lifestyle. Genes are the deepest layer of individualization. When a patient is doing incredibly well despite horrible genetic deficiencies, it is a strong deterrent to fall off the wagon.
  2. Creates the last thrust of motivation for a patient who is having trouble adhering to their diet and lifestyle protocol.
  3. Provides incredible proof for prevention of family disease history. Connects the dots for many of our patients.
  4. Is a strong component for new patient screenings, especially for methylation, detoxification, antioxidant defense, weight management, metabolic health, memory and cognition, mental health, and essential fatty acid, vitamin A, and vitamin D absorption.
Videos
Video: Face Yoga
New study in JAMA Dermatology found facial appearance benefits from 30 minutes daily of face yoga for 20 weeks!
 
Far Infrared Sauna Therapy
 
Steve: Traditional saunas emit direct heat. Far Infrared uses light to create heat. Far infrared run at much milder temperatures, but travels much deeper into the body, which is why you sweat more vigorously.

Far Infrared Therapy offers numerous therapeutic benefits, most importantly enhanced detoxification. Many of our clients use it to relieve painful joints, rev up metabolism, and remove buildup of heavy metals.

Far Infrared has shown to draw out 15 to 20% more heavy metals (i.e., mercury, lead, cadmium, arsenic), hormone-disrupting chemicals, sulfuric acid, ammonia, uric-acid, and fat-soluble toxins than traditional saunas.

A recent study from Age and Ageing, showed that healthy subjects whose sauna use averaged 4 to 7 times per week were 66% less likely to develop dementia at 20-year follow-up than those who used a sauna once a week. In addition, they had a 65% risk reduction for Alzheimer's Disease.

Recent studies in JAMA Internal Medicine and American Journal of Hypertension found that increased frequency of sauna bathing reduced the risk of sudden cardiac death, coronary heart disease, cardiovascular disease, hypertension, and all-cause mortality.

Contact us to schedule a session.
ActionPlan2 
Action Plan of the Month:
Sleep Well
 
One of the benefits of being a NCI Well Connect Member is that you can request two titles monthly from our our Action Plan Library (43 plans: total value $300). 

This comes in handy when you are looking to optimize your wellness habits such as sleep! Our Sleep Well Action Plan is a great primer to say the least! 

Action Plans are free by email request for NCI Well Connect Members or can be ordered separately. To activate your NCI Well Connect Membership at 25% OFF this month, click here.
eNews 
eNews Briefs
WCBenefit 
NCI Well Connect Member Benefits
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NCI Well Connect Membership is open to clients and non-clients of our practice!

One Year Membership Includes:
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Care's Corner Video
Food Intolerance: the Silent Assassin
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Be Your Own Medical Advocate
 
Aspirin-Like Substances in My Food
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Wellness Services Menu
We have a multitude of options for simple fine-tuning or the toughest cases.
  • Full Wellness Evaluation (with bloodwork)
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  • Dietary Supplement Evaluation
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  • Far Infrared Sauna Treatment
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  • Chiropractic and Acupuncture

Consulting prices range from $45 to $225. Contact us at 847-498-3422 or email for details.

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Have a happy, healthy day,
stateofthebonnie 
Bonnie, Steve, Carolyn, Lilo, Elizabeth, and Sharron
(847) 498-3422
nutrocon@aol.com  

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