NCI Well Connect Mid-Week Brief
March 29, 2017
Spring Sale!
Dear Steve, 

DID YOU KNOW that repeated binge drinking during adolescence can affect brain functions in future generations, potentially putting offspring at risk for such conditions as depression, anxiety, and metabolic disorders?

According to a study presented at least year's annual meeting of the Society for Neuroscience, adolescent binge drinking altered the on-off switches of multiple genes in the brain.

When genes are turned on, they instruct cells to make proteins, which ultimately control physical and behavioral traits. The study found genes that normally are turned on were turned off, and vice versa.

The study is the first to show a molecular pathway that teenage binge drinking by either parent can cause changes in the neurological health of subsequent generations.

Starting today until the end of day on March 31st, you can get both March and April sale items at 20% off. See details below.

If you have ordered 23andMe genetics kits in the past, they are offering a special rate ($69 from $99) if you want them for friends and family. The special ends March 31st.

Have a happy, healthy day. Steve and Bonnie
B-Vitamin Linked to Reduced
Colon Cancer Risk
Bonnie and Steve: Authors in a study from the March issue of American Journal of Clinical Nutrition  state that higher blood levels of the vitamin B-6 marker pyridoxal 5'-phosphate have been associated with reduced colorectal cancer (CRC) risk. However, the reason for this has yet to be explained. The authors suspect inflammatory processes, including vitamin B-6 catabolism, could explain it.

This study was special because researchers followed vitamin B-6 status in relation to CRC risk for a 14 year period, the longest study to date. They also measured more vitamin B6-related biomarkers than ever before: PLP, pyridoxal, pyridoxic acid (inflammatory marker), 3-hydroxykynurenine (inflammatory marker), and xanthurenic acids (inflammatory marker).

They found that plasma PLP concentrations were associated with a reduced CRC risk for the highest compared with the lowest blood level group. Those with higher inflammatory markers pyridoxic acid, 3-hydroxykynurenine, and xanthurenic acids had increased CRC risk.

It is pretty clear from this long-term study that vitamin B-6 deficiency is associated with an increase in CRC risk. Furthermore, the analysis of novel markers of functional vitamin B-6 status and vitamin B-6-associated oxidative stress and inflammation suggest a role in tumor progression.

In our opinion, testing for blood levels of B6 should eventually become routine. More importantly, discovering whether you can break down vitamin B6 genetically into absorbable pyridoxal 5'-phosphate is essential. Our Pure Genomics panel screens for this.
Mindfulness and Depression

This article is reserved for NCI Well Connect Members. You can get this article by signing up for NCI Well Connect!
New Genetics Wellness Panel!
Weight Maintenance, Metabolic Health
Bonnie and Steve: It only takes a few simple steps to get individualized genetic nutritional support. Test your genome. We translate the results in a way you can understand. We target your individualized needs with nutritional support that can be easily implemented.

NCI Well Connect Member Benefits
One Year Membership Includes:
  1. Award-Winning eNewsletters. We publish our long-form issue on Monday and a mid-week brief on Wednesday. Recent preview issue here.
  2. Self-Help Action Plans. Access to two titles per month from our self-help Action Plan Library. There are currently 43 Action Plan titles to date on all aspects of wellness, including the new Heal Your Headache Action Plan. You can view the full library of titles here.
  3. Natural Foods Shopping List. Updated quarterly, our Natural Foods Shopping List includes only the most meticulously vetted, highest quality food and beverage products that we recommend to our clients. These include gluten-free, corn-free, and kosher pareve items.
  4. 30 Minutes Free Pure Genomics Analysis & Coaching (Consult with Steve; Bonnie's consult would be separate).
The approximate cost for all of this? Less than one dollar a week!
We appreciate your continued patronage and support.

Need to search for information from past issues? Type in the word(s) in the google search box at this link.

Have a happy, healthy day,

Bonnie, Steve, Carolyn, Lilo, Elizabeth, Sharron, and Jeannie
(847) 498 3422

M-F 9AM-5PM, SAT 9-4