NCI Well Connect Mid-Week Brief
August 22, 2018
Dear Steve, 

DID YOU KNOW that surprisingly, a few clients have found Pure Encaps Mineral2O to have an unpleasant taste? For these individuals, we suggest adding freshly squeezed lemon and liquid stevia into your water or tea.

NutriBiotic Dental Gel is on back order until the end of September. While it is out, we recommend: Magic Mud Charcoal Toothpaste (prepare for charcoal residue on the sink though) and Tom's of Maine Fluoride-Free Toothpaste Gel.

UP4 Daily has been discontinued. For an apples to apples replacement, we suggest Klaire Labs Probiotic Complex.

If you need a list of cross-reacting foods to remove from your diet for the next four to eight weeks, as well as foods to replace them, our Conquering Allergy and Intolerance Action Plan has it covered. Free by email to NCI Well Connect members or can be ordered separately at our website.

Have a happy, healthy day! Steve and Bonnie
Our First Clinical Study, Part Two
Bonnie and Steve: Last month, we reported on part one of our first clinical study, showing a link between FTO genetic mutations and overweight and obesity (click here for a link to the story).

We are delighted to announce that part two of first clinical study is complete!

We would like to give a huge thank you to our summer intern, Rachel Sachs, who did much of the heavy lifting!

Part Two of our study, which delved much deeper into our Pure Genomics data, produced some incredible results!

In our clinical setting, assess the link between genetic mutations and five of the most common chronic conditions plaguing modern humans today:
  1. Alzheimer's Disease/Dementia
  2. Cancer
  3. Diabetes
  4. Arthritis
  5. Depression
  1. Analyze each client's file to ascertain if prior to their first visit with us, did they have one or more of these chronic conditions themselves or in their family history.
  2. Analyze each client's Pure Genomics genetic report and tabulate whether he/she had one, two, or no mutations for genes associated with the five chronic conditions.

Alzheimer's Disease/Dementia
BDNF gene - no increased risk with mutations;
DRD2 gene - much higher risk with mutations; highest risk for one mutation;
MTHFR (C677T) gene - slightly increased risk with mutations; higher risk with one mutation;

COMT gene - much higher risk with mutations; highest for one mutation; still very high for two mutations;
GSTP1 gene - no increased risk with mutations;
TNF-alpha gene - much higher risk if no mutations (significant because it has been shown that having TNF-alpha mutations, while increasing allergy risk, is better for cancer risk);

ADR2A gene - no increased risk with mutations;
SLC0A8 gene - the most significant finding of the study; 91.8% increased risk with one or two mutations; only 8.2% with diabetes had no mutations; this gene has to do with absorbing zinc;
TCF7L2 gene - no increased risk with mutations;

COMT gene - much higher risk with mutations; highest for one mutation;
IL-6 gene - very high risk with mutations; highest for one mutation;

COMT gene - much higher risk with mutations; highest for one mutation;
TPH2 gene - no increased risk with mutations;
MTHFR (A1298) gene - no increased risk with mutations;

  • Mutations of the COMT gene, which is the most important part of the methylation cycle, greatly increases the risk of cancer, arthritis, or depression;
  • Mutations of the IL-6 gene greatly contributes to the risk of arthritis;
  • Mutations of the SLC0A8 gene immensely contributes to the risk of diabetes. 91.8% of those with mutations had diabetes themselves or in their family history. The importance of having proper zinc stores cannot be understated! 
  • No mutations of the TNF-alpha gene increases of cancer. As we have said in the past, having some genetic mutations is not a bad thing. In the case of TNF-alpha, mutations protect against cancer.
  • Mutations of DRD2 gene and MTHFR (C677T), the former more than the latter, increases the risk of Alzheimer's Disease/Dementia.
The results from this clinical study should not be looked upon as a death sentence. As we have said incessantly, every one of the genes can be positively modified with diet and lifestyle.

To act badly, genetic mutations must be unlocked by poor lifestyle choices. Our job is to help you prevent your genes from acting badly, or if already doing so, mitigate it with optimal diet and lifestyle.

Unless you learn about your genetic mutations, however, we cannot ascertain your individual needs. Think about how much you can help yourself, your family, and future generations with this knowledge.
Gerolsteiner Alternative
Bonnie and Steve: We know that you love Gerolsteiner sparkling water. All of our family and staff love it too! However, there are some that do not care for Gerolsteiner, or find it cumbersome to purchase glass bottles.

We are delighted that Pure Encapsulations has launched Mineral2O, which is basically Gerolsteiner in "powder" form. Just add a tiny scoop to 8 oz. of water and that's it!

Here are some of the reasons why Mineral2O is so ideal:
  • It's portable. Much easier to bring with on vacations or to the gym. You can put a scoop into your water bottle and have an instant electrolyte water/mineral supplement.
  • The downside of a reverse osmosis filter is it removes all minerals. Also, if you live in a location with soft water, there are few minerals. Mineral2O can replace many of these for you.
  • Provides every essential electrolyte, but is very low in sodium. We get so much more sodium in our diets than all other electrolytes. You can add sea salt to your water if you need more sodium.
  • Perfect for athletes and those who exercise vigorously for before and after workouts/athletic events.
  • Better tolerated for those with absorption issues or chronic diarrhea.
  • When you have stomach flu or an intestinal virus that causes acute diarrhea, Mineral2O with a well tolerated sugar, such as maple syrup, could be awonderful alternative to the dehydration formulas that are loaded with corn and preservatives.
  • You could reduce your calcium and magnesium supplement intake. Consult with your health professional before doing so.
  • It's alkalizing. Along with calcium, magnesium, and chloride, Mineral2O contains 72 trace minerals, most of which are alkalizing.
Please direct any product questions by email to Steve.
Steve Authors Genetic Study
FTO Gene Study Results Positive
On the heels of our first-ever analysis of genetic data at Nutritional Concepts, I have followed up these findings with a research study that will be submitted to journals for potential publishing.

As part of my masters degree studies, I was asked to author a study on any wellness topic that interested me. Of course, I thought of you first. I wanted to canvas all relevant data to ascertain if FTO gene mutations increase the risk of overweight and obesity.

FTO gene is one we screen for in our Pure Genomics panel, and is the most researched to date with regard to overweight and obesity. I evaluated 113 studies about the FTO gene, narrowed it down to 55 that met my criteria, and for the paper, could only choose 7 to highlight.

The study does meet all scientific requirements, so for many of you it will be a bland read. I just wanted you to know how important it is that what I recommend to our clients is backed by, and heavily vetted from, research.

If interested, you can click on the title below to read my study:

Do FTO Gene Mutations Raise the Risk of Overweight and Obesity? 
Recipe Du Jour 
This article is reserved for NCI Well Connect Members. You can get this article by signing up for NCI Well Connect here today!


Bonnie: I love to make slaws because I can use up whatever veggies I have on hand (i.e., carrots, broccoli, onions)....

You can get this recipe by signing up for NCI Well Connect here today!
Genetic Wellness Screening 

Pure Genomics, our genetic wellness screening, covers 32 impeccably well-researched genes in seven categories:
  1. Methylation
  2. Vitamins and Minerals
  3. Detoxification
  4. Weight Management
  5. Cognitive Health and Memory
  6. Blood Sugar Balance
  7. Immune Health
Pure Genomics tips the balance toward optimal wellness. It only takes four simple steps to get started:
  1. Order a genetic kit from or
  2. Send your saliva sample back to 23andMe or Ancestry. They will email you when your results are ready.
  3. Download your raw genetic data file to your computer. Email us the data file.
  4. We generate your Pure Genomics report and contact you with the next step.
Email Steve for further questions or clarification.
NCI Well Connect Member Benefits 

One Year Membership Is Open to Clients and Non-Clients.
Membership Includes:
  1. Free 45 Minute Pure Genomics Screening & Consultation
  2. Twice Weekly eNewsletters. Long-form issue on Monday and mid-week brief on Wednesday.
  3. Self-Help Action Plans. Access to two titles per month from our 44 title self-help Action Plan Library. Full library of titles here.
  4. Natural Foods Shopping List. Meticulously vetted, high quality food and beverages we recommend to our clients. Gluten-free, corn-free, and kosher pareve items included. Updated quarterly.
We appreciate your continued patronage and support.

Need to search for information from past issues? Type in the word(s) in the google search box at this link.

Have a happy, healthy day,
Bonnie, Steve, Carolyn, Lilo, Elizabeth, Sharron, and Lori
(847) 498 3422

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