ActiFolate

Complete Folate Nutrition Dietary Supplement

-800 mcg. pharmaceutical grade Folic Acid, 5-Formyl Tertahydrofolate, and L-5-methyl tetrahydrofolate
-60 vegetarian tablets (two month supply) -- $12.99 per bottle
-Recommended one tablet daily after breakfast for maintenance
-FDA approved to be exclusively sold as a dietary supplement by Metagenics
-Ingredients: Folic Acid, 5-Formyl Tertahydrofolate, and L-5-methyl tetrahydrofolate, microsrystalline cellulose, stearic acid, silica, and modified cellulose coating.

What is it?
Folic Acid, 5-Formyl Tertahydrofolate, and L-5-methyl tetrahydrofolate are needed for folate to be metabolized. Folic Acid needs to be converted to 5-Formyl Tertahydrofolate, which needs to converted to L-5-methyl tetrahydrofolate, the active and isomeric form of folate in the blood. Have a complete folate nutritional supplement is especially important for those individuals (roughly 25% of humans) who do not have the ability to activate folic acid due to genetic variability (what is called a MTHFR enzyme deficiency). While it is very expensive to test this gene for deficiency, it is inexpensive to supplement with ActiFolate for assured folate metabolism.

What Does it Do?
Folates are essential water-soluble vitamins that are involved in DNA synthesis and have a high potential for normalizing homocysteine plasma levels.

Humans cannot synthesize folates in the body and must thus obtain them from dietary sources. Green vegetables in particular are rich in folate but otherwise hard to find in nature. During processing and cooking, significant amounts of food folate are lost. 

According to the foremost researchers on genetically inherited folate enzyme insufficiency, Professor Rowena Matthews at University of Michigan, “About 15 percent of all Americans may be particularly vulnerable to folic acid deficiency.”  A 1997 The Lancet study echoes this statement.

Who Should Take it?
Low folate has been associated with various disorders such as:

§         Cardiovascular Disease

§         Alzheimer’s disease

§         Neural tube defects

§         Megaloblastic anemia

§         Colon Cancer

In some cases, these disorders could be linked to inefficient MTHFR enzyme activity. ActiFolateä assures that each folate cycle is accounted for.

Actifolateä is suggested for the following (or have in family history):

§         Cardiovascular Disease

§         Homocysteinemia (mild, moderate, or severe)

§         Neural tube defects

§         Prenatal, Pregnant, or Lactating

§         Megaloblastic anemia

§         Smoking

§         Salicylate Sensitivity

§         Dementia or Alzheimer’s disease

§         Cancer (especially colon)

§         Depression

§         Serotonin deficiency

§         Stress-related conditions

§         Support growth in children

§         Age-related conditions

§         Chronic alcoholism

§         Coeliac disease

§         Anticonvulsant, Corticosteroid, NSAIDs, Oral Contraceptive, Metformin, Methotrexate, Trimethoprim-containing antibiotics, and/or Sulfasalazine
consumption

§         Synthetic estrogen consumption

How Does it Compare to Other Folic Acid Products?
Folic Acid supplements are the most common form used for supplementation. They are synthetic and virtually unknown in nature. It only becomes biologically active by enzymatic conversion steps (must be reduced and methylated during and after absorption). It is believed that up to 25% of human beings do not have the ability to make the conversion. ActiFolateä is an exclusive, patented formula made for Metagenics which accounts for all steps in the folate cycle to assure the natural form of folate is directly taken up by the cell.

When Can I Take it?
One tablet daily after breakfast for maintenance. Please refer to your licensed health professional for therapeutic dose.

Any Side Effects with Herbs or Drugs?
No known interactions. We always recommend consulting with your physician.

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Actifolateä click Supplements
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References

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(see another full set of references attached)