Simple Sleep Solutions

From eNewsletter 11/19/2025

DID YOU KNOW that pyridoxal 5′-phosphate (activated vitamin B6) serves as the essential cofactor converting tryptophan into serotonin, which your body then transforms into natural melatonin? P-5-P also supports GABA synthesis for nervous system calming.

Thus, those with chronic sleep disturbance often respond to this form of vitamin B6 due to its impact on GABA and serotonin pathways. So instead of flooding your system with external hormones like melatonin, P-5-P can support your brain’s own sleep architecture.

The one drawback is that 50-100mg daily is usually needed for sleep enhancement, taken 30-60 minutes before bedtime. This amount can be contraindicated for many of you, so do not try this without discussing it with us or your physicians.

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