Whole Grain Train Derailed?

From eNewsletter 4/13/2026

DID YOU KNOW that for almost two decades, we have been recommending "activated" folate instead of basic folic acid supplements?

We understood early on that many of us cannot metabolize folate as presented as folic acid because of genetic mutation. Folic acid needs to be reduced enzymatically twice before being absorbed. If you are genetically predisposed, you will not adequately metabolize folic acid into usable folate.

This is particularly critical for those in their fertility years and older persons. A new study from Frontiers in Nutrition found that women who had "activated folate" in their prenatal supplement exhibited much less unmetabolized folate in their blood. Hence, they were absorbing it better.

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