How Low Should LDL GO?

From eNewsletter 6/8/2026

DID YOU KNOW that according to a study from Cardiovascular Diabetology, the lower your LDL cholesterol (LDL-C), the higher the risk for type 2 diabetes (T2D) in individuals without a prior history of T2D and cardiovascular disease?

Baseline LDL-C levels of participants were: low (< 84 mg/dL), medium (≥ 84 to < 107 mg/dL), high (≥ 107 to < 131 mg/dL), and very high (≥ 131 mg/dL).

Overall, 13% of participants developed incident T2D. The incidence was 20% among statin users and 6% among non‑users. Lower LDL-C levels were associated with a higher risk for incident T2D, with participants in the low LDL-C group (< 84 mg/dL) having the highest risk.

Given that many physicians and cardiologists are pushing for LDL-C levels below 70 due to the ACC/American Heart Association Updated Guidelines, this is problematic.

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