Supps for Depression

From eNewsletter 8/20/2025

DID YOU KNOW that a new review study from Frontiers in Pharmacology examined 64 over-the-counter supplements and herbs that are used for depression? The study included adults aged 18-60 years with depression symptoms or a diagnosis.

Of the supplements with most evidence, St John's Wort, saffron, probiotics, vitamin D3, and omega-3's were more likely to reduce depressive symptoms than placebo in that order. Some showed to be just as effective as antidepressants.

Of the supplements with emerging evidence, folic acid, lavender, zinc, 5-hydroxy tryptophan, rhodiola, lemon balm, melatonin, magnesium, and curcumin were the most promising.

While there were very few safety concerns, we never recommend self-supplementing for depression. Always seek assistance from a knowledgable health professional.

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