Diet and Your Pain

From eNewsletter `10/6/2025

DID YOU KNOW that there were two incredible studies published about B-vitamins?

Optimal concentrations of folate and vitamin B12 significantly reduce serum homocysteine concentrations as well as mitigate the genetic impact? Elevated homocysteine is indicated for stroke, osteoporosis, and memory loss.

Researchers in a study from The Journal of Nutrition found individuals deficient in both vitamin B12 and folate had an increased risk of hyperhomocysteinemia (57.4%). In contrast, the prevalence was lower among those deficient in either vitamin B12 (31.1%) or folate (23.2%) alone. Significant associations were identified between the MTHFR C677T and A1298C genetic polymorphisms and elevated serum homocysteine concentrations. 

Thus, supplementing with the correct sources of vitamin B12 and folate that circumvent genetic mutations is more effective than those that do not.

A large retrospective study from JAMA Dermatology of Veterans Affairs patients with a history of skin cancer purports that patients taking nicotinamide (a non-flush source of niacin) 500 mg twice daily can significantly reduce their risk for skin cancer, with the greatest effect seen in those who take the supplement after their first episode of skin cancer.

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