Special Issue: Heathspan, Cell Rejuvenation
From eNewsletter 4/20/2022
DID YOU KNOW that triglycerides are finally getting the respect they deserve for their importance to your health? Triglycerides are part of a standard lipid panel. Until recently, physicians have not paid as much attention to this diagnostic tools as others such as LDL cholesterol. It seems the tide is turning. For example, a new study from Neurology suggests that people who have a stroke along with higher levels of triglycerides, have a higher risk of having another stroke or other cardiovascular problems one year later, compared to people who had a stroke but have lower triglyceride levels. Another study from Nutrients suggests that men with high triglycerides have a higher risk of prostate cancer and should be monitored more closely. High triglycerides also can accelerate the aging process, which we will explain more in detail below.
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Have a happy, healthy day! Steve and Bonnie Minsky
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Healthspan, Cell Rejuvenation
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Special Issue: Healthspan, Cell Rejuvenation
Steve: For any adult age group, there is no better time to initiate cell rejuvenation than right now. Not only will the following help you short-term, but for the long-term, in the form of optimizing your longevity and quality-of-life. This is what we call healthspan, or, the number of years we can live well without disease. Cell rejuvenation is especially prescient for those suffering from post-COVID syndrome, chronic disease, mental and physical fatigue, among others. So what solutions can we install to induce cell rejuvenation? Fight AGEs Advanced glycation end products (AGEs), created mostly by sugary foods, speed up cell-death and like the acronym says, speeds up the aging process. As new studies from Nutrition Reviews and Cell Reports allude to, we can only renew our cells so many times, so the less we have to do so, the longer our healthspan will be. Aside from avoiding sugar as much as possible, consumption of a diet rich in monounsaturated fatty acids, such as olive oil, and omega-3 fatty acids from fish, lowers blood concentrations of AGEs. Supplementation with EPA/DHA omega-3 fatty acids result in decreased concentrations of AGEs as well. Diagnostically, if you are looking for common indicators of excess AGEs, look no further than high levels of triglycerides and hemoglobin A1C. Nutrition Good nutrition rejuvenates cells and modulates aging. Choosing the right carbohydrates rich in vegetables and fruit, nuts, fiber-rich, well-tolerated grains, fish, poultry, olive oil, and omega-3 fatty acids, lower cardiovascular diseases and obesity risk, protect the brain from aging, reduces the risk of telomere shortening, and promote a better overall quality of life. Thus, according to studies from Nutrients and Advances in Nutrition, adhering to one’s optimal nutritional patterns is crucial to prevent the emergence and development of diseases, boost longevity, and, mostly, to enhance one’s quality of life and promote healthy aging. Sarcopenia, or muscle loss, which we have discussed a lot recently, is one of the foremost aspects of aging, but can be prevented by consuming optimal amounts of bioavailable protein (older adults need more) and performing consistent physical activity, according to a study in Nutrients. Dietary Supplements While nutrition via optimal eating style is predominately responsible for cell rejuvenation, it is hard to actually reverse biological aging without outside assistance, even when adhered to for years. Thus, we must include dietary supplements such as quercetin, fish oil, ellagic acid, Urolithin A, astaxanthin, reduced glutathione, Coenzyme Q10, and beet root extract, to name a few. These need to be individualized based upon intolerances, genetic predisposition, among others. Moreover, our mitochondria, which energize the cell and keeps our cells young, require huge amounts of antioxidants because they are constantly producing energy, which create toxic metabolites called free radicals. As referenced in a Nature study, free radicals need to be neutralized by antioxidants. which we get from select phytonutrients in fruit, vegetables, spices, and dietary supplements. If we have a mutation of the glutathione gene (which can be found in our Pure Genomics panel), we need even more support than the average individual. Staying Active Lifelong physical activity protects against age-related loss of muscle mass and function, or sarcopenia, according to research in The Journal of Physiology. Individuals aged 68 and above who are physically active throughout their lives have healthier aging muscle that has superior function and is more resistant to fatigue compared to inactive individuals, both young and old. Those taking part in resistance exercise, ball games, racket sports, swimming, cycling, running and/or rowing had a greater number of muscle stem cells. That said, even starting late-life physical activity can have rejuvenating effects, according to a new study from Aging Cell. Stress Stress is positively associated with accelerated biologic aging, according to a study from Translational Psychiatry. Good self-control is protective against the negative consequences of stress on aging. Of course, stress reduction practices such as deep breathing, meditation, mindfulness, and yoga are just some of the many techniques that can be employed. Sleep At least 6-8 hours of quality sleep per night is essential. The ideal time to go to bed is around 9:30PM. Conclusion As evidenced by the aforementioned, cell rejuvenation, and even reversing the aging process, is possible. However, it takes a tremendous amount of work and discipline to adhere to all of the above. All we can ask is that you put in as much effort as possible without over-stressing your body mentally and physically. You have the tools to implement this over time and at your own pace. And of course, we are here to help you every step of the way.